| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
Dry Extract of Passiflora incarnata L. leaves as a Cardiac and Hepatic Oxidative Stress Protector in LDLr-/- Mice Fed High-Fat Diet
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| Autores: |
Sarto,Danielle Aparecida Quintino Silva
Siqueira,Ana Helena D’Arcadia de
Magalhaes,Francisco Monteiro de Almeida
Caproni,Karine de Paula
Martins,Ângela Maria
Santos,Gérsika Bitencourt
Silva,Délcio Bueno da
Boas,Brígida Monteiro Vilas
Garcia,José Antônio Dias
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| Data: |
2018-01-01
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| Ano: |
2018
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| Palavras-chave: |
Passion fruit
Left ventricular hypertrophy
Dyslipidemia
Oxidative stress
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| Resumo: |
ABSTRACT The control of dyslipidemia by using herbal products is an important subject for studies. In this study, we evaluated the effects of dry Passiflora incarnata L. extract over dyslipidemia, left ventricular hypertrophy, and hepatic oxidative stress of LDL receptor knockout mice (LDLr-/-). Forty 4-month old male LDLr-/- mice were distributed into four groups: Group standard diet; Group standard diet and 200 mg/kg of body weight of Passiflora incarnata L. leaf dry extract; Group high-fat diet; Group high-fat diet and 200 mg/kg of body weight of Passiflora incarnata L. leaf dry extract. After 30 days, Passiflora incarnata L. dry extract reduced the effects of the high-fat diet, with a decrease of total cholesterol, triglycerides, and increase of high-density lipoprotein (HDL), as well as a reduction of C-reactive protein, alkaline phosphatase and insulin. There was no effect on glucose, Homa index and enzymes aspartate aminotransferase and alanine aminotransferase. However, the prevention of left ventricular hypertrophy occurred, as well as lipid peroxidation and the production of carbonyl proteins, which are both oxidative stress markers. In conclusion, Passiflora incarnata L. dry extract acts in the prevention of dyslipidemia, consequently, hindering the occurrence of hepatic oxidative stress and the development of left ventricular hypertrophy by the increase of serum HDL, in mice that had the effects of a high-fat diet.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132018000100321
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/1678-4324-2018180147
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.61 2018
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| Direitos: |
info:eu-repo/semantics/openAccess
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