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Provedor de dados:  BABT
País:  Brazil
Título:  Induction of an antigen specific gut inflammatory reaction in mice and rats: a model for human Inflammatory Bowel Disease
Autores:  Teixeira,Gerlinde Agate Platais Brasil
Antunes,Danielle Mota Fontes
Castro Júnior,Archimedes Barbosa de
Costa,Janilda Pacheco da
Paschoal,Patrícia Olaya
Campos,Sylvia Maria Nicolau
Pedruzzi,Monique de Morais Bitetti
Araújo,Vinicius da Silva
Andrade,Luis Antônio Botelho
Moreno,Silvana Ramos Farias
Nobrega,Alberto Felix Antonio da
Cardoso,Gilberto Perez
Data:  2009-06-01
Ano:  2009
Palavras-chave:  Food allergy
Inflammatory bowel disease
Resumo:  Food allergy is an adverse reaction that occurs in susceptible people when they eat sensitizing foods and is one of the causes of Inflammatory Bowel Disease (IBD). The effort to understand the induction process of these diseases is important as IBD is increasing worldwide, including in Brazil. The aim of this study was to develop an experimental antigen specific inflammatory process of the gut of mice and rats, using peanut seeds. Animals were immunized with peanut protein extract before their exposure to the in natura peanut seeds. Results showed that systemic immunization with peanut protein extracts rendered significantly higher antibody titers than control groups and that immunized animals submitted to a challenge diet containing peanuts presented time dependent alterations of the gut similar to celiac disease. In conclusion, results suggested that this experimental model was a convenient tool to study the evolution of alterations in chronic antigen specific gut inflammatory process.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Editor:  Instituto de Tecnologia do Paraná - Tecpar
Relação:  10.1590/S1516-89132009000300012
Formato:  text/html
Fonte:  Brazilian Archives of Biology and Technology v.52 n.3 2009
Direitos:  info:eu-repo/semantics/openAccess

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