| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
Role of Carnosine and Melatonin in Ameliorating Cardiotoxicity of Titanium Dioxide Nanoparticles in the Rats
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| Autores: |
Al-Rasheed,Nouf
Faddah,Laila
Ibrahim,Hanan
Mohamed,Azza M
Al-Rasheed,Nawal
Abdelbaky,Nayira
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| Data: |
2015-08-01
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| Ano: |
2015
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| Palavras-chave: |
Titanium dioxide nanoparticles
Cardiotoxicity
Carnosine
Melatonin
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| Resumo: |
The aim of this work was to study the possible cardiotoxicity of two different doses of 50 nm nano titanium dioxide (n-TiO2) and the possible modulating effects of the use of two natural antioxidants carnosine and melatonin. The results showed that TiO2- NPs produced deleterious effects on rat cardiac tissue as confirmed by the increased levels of serum myoglobin, troponin-T and CK-MB. Increased levels of serum Inflammatory markers represented by the tumor necrosis factor alpha (TNF-α) and Interleukin-6 (IL-6) was also noticed. Caspase3 and IGg were elevated compared to the control group in a dose dependant manner. treatment of the rats with Carnosine or melatonin. along with TiO2- NPs administration significantly improved most of the elevated biochemical markers. It was concluded that the use of Carnosine or melatonin could play a beneficial role against deleterious effects of TiO2- NPs
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000400577
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/S1516-8913201500014
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.58 n.4 2015
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| Direitos: |
info:eu-repo/semantics/openAccess
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