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Provedor de dados:  BJID
País:  Brazil
Título:  Pathogenic and opportunistic respiratory bacteria-induced apoptosis
Autores:  Lancellotti,Marcelo
Pereira,Rafaella Fabiana Carneiro
Cury,Gisele Gentile
Hollanda,Luciana Maria de
Data:  2009-06-01
Ano:  2009
Palavras-chave:  Pathogenic bacteria
Opportunistic bacteria
Apoptosis
Bacteria induce apoptosis
Respiratory bacteria
Resumo:  Several pathogenic or opportunistic bacteria have the ability to either induce or inhibit host cell apoptosis. The capacity to modulate cell pathways that result in the induction or delay of host cell apoptosis is considered to be an important bacterial virulence mechanism. These processes could be mediated by different host cell signaling pathways that are subverted by the bacteria. Pathogens are able to activate apoptotic proteins, such as caspases, or inactivate anti-apoptotic proteins, such as NFkB and the MAPKKs, or even up-regulate the endogenous receptor/ligand system that induces apoptosis, generally when the bacteria are bound to the host cell surface. The bacteria-induced apoptotic or anti-apoptotic processes are often related with the fact that the bacteria acquire the ability to reach the host tissues. However, apoptosis is also considered to be a host defense mechanism against infectious agents. Thus, the apoptosis phenomenon plays a central role in host-pathogen interactions.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300014
Editor:  Brazilian Society of Infectious Diseases
Relação:  10.1590/S1413-86702009000300014
Formato:  text/html
Fonte:  Brazilian Journal of Infectious Diseases v.13 n.3 2009
Direitos:  info:eu-repo/semantics/openAccess
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