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Provedor de dados:  55
País:  Brazil
Título:  Induction of apoptosis by zerumbone isolated from Zingiber zerumbet (L.) Smith in protozoan parasite Leishmania donovani due to oxidative stress
Autores:  Mukherjee,Debarati
Singh,Chingakham Brajakishor
Dey,Somaditya
Mandal,Supratim
Ghosh,Joydip
Mallick,Suvadip
Hussain,Aabid
Swapana,Ningombam
Ross,Samir Anis
Pal,Chiranjib
Data:  2016-02-01
Ano:  2016
Palavras-chave:  Leishmania donovani
Zingiber zerumbet
Zerumbone
Anti-leishmanial
ROS
Resumo:  Abstract In the present context of emergence of resistance aligned with the conventional anti-leishmanial drugs and occasional treatment failure compelled us to continue the search for replaceable therapeutic leads against Leishmaniainfection. Various ginger spices of the Zingiberaceae family are widely used as spices, flavouring agents, and medicines in Southeast Asia because of their unique flavour as well as due to their medicinal properties. Zerumbone, a natural component of Zingiber zerumbet (L.) Smith, has been studied for its pharmacological potential as antiulcer, antioxidant, anticancer, and antimicrobial. In this study, we have shown that zerumbone could induce ROS mediated apoptosis in Leishmania donovani promastigotes and also found effective in reducing intracellular amastigotes in infected-macrophages. We emphasized the potential of zerumbone to be employed in the development of new therapeutic drugs against L. donovaniinfection and provided the basis for future research on the application of transitional medicinal plants.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000100048
Editor:  Brazilian Society of Infectious Diseases
Relação:  10.1016/j.bjid.2015.10.002
Formato:  text/html
Fonte:  Brazilian Journal of Infectious Diseases v.20 n.1 2016
Direitos:  info:eu-repo/semantics/openAccess
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