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Provedor de dados:  BJID
País:  Brazil
Título:  Serum markers as an aid in the diagnosis of pulmonary fungal infections in AIDS patients
Autores:  Passos,Ana Isabela Morsch
Dertkigil,Rachel Polo
Ramos,Marcelo de Carvalho
Busso-Lopes,Ariane Fidelis
Ribeiro,Erivan Olinda
Schreiber,Angélica Zaninelli
Resende,Mariangela Ribeiro
Moretti,Maria Luiza
Data:  2017-12-01
Ano:  2017
Palavras-chave:  Pulmonary infection
Fungal infection
Resumo:  ABSTRACT Introduction: The etiology of pulmonary infections in HIV patients is determined by several variables including geographic region and availability of antiretroviral therapy. Materials and methods: A cross-sectional prospective study was conducted from 2012 to 2016 to evaluate the occurrence of pulmonary fungal infection in HIV-patients hospitalized due to pulmonary infections. Patients’ serums were tested for (1-3)-β-D-Glugan, galactomannan, and lactate dehydrogenase. The association among the variables was analyzed by univariate and multivariate regression analysis. Results: 60 patients were included in the study. The patients were classified in three groups: Pneumocystis jirovecii pneumonia (19 patients), community-acquired pneumonia (18 patients), and other infections (23 patients). The overall mortality was 13.3%. The time since diagnosis of HIV infection was shorter in the pneumocystosis group (4.94 years; p = 0.001) than for the other two groups of patients. The multivariate analysis showed that higher (1-3)-β-D-Glucan level (mean: 241 pg/mL) and lactate dehydrogenase (mean: 762 U/L) were associated with the diagnosis of pneumocystosis. Pneumocystosis was the aids-defining illness in 11 out of 16 newly diagnosed HIV-infected patients. Conclusion: In the era of antiretroviral therapy, PJP was still the most prevalent pulmonary infection and (1-3)-β-D-Glucan and lactate dehydrogenase may be suitable markers to help diagnosing pneumocystosis in our HIV population.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Editor:  Brazilian Society of Infectious Diseases
Relação:  10.1016/j.bjid.2017.07.002
Formato:  text/html
Fonte:  Brazilian Journal of Infectious Diseases v.21 n.6 2017
Direitos:  info:eu-repo/semantics/openAccess

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