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Provedor de dados:  BJID
País:  Brazil
Título:  Galactomannan detection from piperacillin-tazobactam brands available in the Brazilian market
Autores:  Xavier,Melissa Orzechowski
Pasqualotto,Alessandro Comarú
Aquino,Valério Rodrigues
Sukiennik,Teresa Cristina Teixeira
Severo,Luiz Carlos
Data:  2009-10-01
Ano:  2009
Palavras-chave:  Piperacillin-tazobactam
Aspergillosis
Platelia Aspergillus
Galactomannan
Resumo:  Piperacillin-tazobactam is a broad spectrum antimicrobial agent that can cause false-positive results in the commercial Platelia Aspergillus EIA test. So far, no study has been performed in Latin America to evaluate the clinical implication of this finding. Here we studied the potential for galactomannan detection in piperacillin-tazobactam batches commercialized in the Brazilian market. Five batches from distinct laboratories were tested in duplicate in the Platelia Aspergillus EIA according to the manufacturer's instructions. Only one drug showed crossreaction at a cut-off of 0.5. Human serum was spiked with this particular drug aiming to mimic achievable piperacillin-tazobactam concentrations in the serum. Results were all negative for galactomannan detection, even at high drug concentrations. Results from this pilot study suggest that piperacillin-tazobactam might not be a clinically significant cause of false-positive results in the Platelia Aspergillus EIA test in Brazil.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500007
Editor:  Brazilian Society of Infectious Diseases
Relação:  10.1590/S1413-86702009000500007
Formato:  text/html
Fonte:  Brazilian Journal of Infectious Diseases v.13 n.5 2009
Direitos:  info:eu-repo/semantics/openAccess
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