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Provedor de dados:  BJMBR
País:  Brazil
Título:  Snake venom metalloproteinases and disintegrins: interactions with cells
Autores:  Kamiguti,A.S.
Zuzel,M.
Theakston,R.D.G.
Data:  1998-07-01
Ano:  1998
Palavras-chave:  Venom
Metalloproteinase
Disintegrin
Platelet
Integrin
Signaling
Resumo:  Metalloproteinases and disintegrins are important components of most viperid and crotalid venoms. Large metalloproteinases referred to as MDC enzymes are composed of an N-terminal Metalloproteinase domain, a Disintegrin-like domain and a Cys-rich C-terminus. In contrast, disintegrins are small non-enzymatic RGD-containing cysteine-rich polypeptides. However, the disintegrin region of MDC enzymes bears a high degree of structural homology to that of the disintegrins, although it lacks the RGD motif. Despite these differences, both components share the property of being able to recognize integrin cell surface receptors and thereby to inhibit integrin-dependent cell reactions. Recently, several membrane-bound MDC enzymes, closely related to soluble venom MDC enzymes, have been described in mammalian cells. This group of membrane-anchored mammalian enzymes is also called the ADAM family of proteins due to the structure revealing A Disintegrin And Metalloproteinase domains. ADAMs are involved in the shedding of molecules from the cell surface, a property which is also shared by some venom MDC enzymes.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000700001
Editor:  Associação Brasileira de Divulgação Científica
Relação:  10.1590/S0100-879X1998000700001
Formato:  text/html
Fonte:  Brazilian Journal of Medical and Biological Research v.31 n.7 1998
Direitos:  info:eu-repo/semantics/openAccess
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