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Provedor de dados:  56
País:  Brazil
Título:  Remodeling in the ischemic heart: the stepwise progression for heart
Autores:  Stefanon,I.
dos Santos,L.
Baldo,M.P.
Data:  2011-09-01
Ano:  2011
Palavras-chave:  Coronary occlusion
Inflammation
Collagen remodeling
Mechanical dysfunction
Heart failure
Rats
Resumo:  Abstract Coronary artery disease is the leading cause of death in the developed world and in developing countries. Acute mortality from acute myocardial infarction (MI) has decreased in the last decades. However, the incidence of heart failure (HF) in patients with healed infarcted areas is increasing. Therefore, HF prevention is a major challenge to the health system in order to reduce healthcare costs and to provide a better quality of life. Animal models of ischemia and infarction have been essential in providing precise information regarding cardiac remodeling. Several of these changes are maladaptive, and they progressively lead to ventricular dilatation and predispose to the development of arrhythmias, HF and death. These events depend on cell death due to necrosis and apoptosis and on activation of the inflammatory response soon after MI. Systemic and local neurohumoral activation has also been associated with maladaptive cardiac remodeling, predisposing to HF. In this review, we provide a timely description of the cardiovascular alterations that occur after MI at the cellular, neurohumoral and electrical level and discuss the repercussions of these alterations on electrical, mechanical and structural dysfunction of the heart. We also identify several areas where insufficient knowledge limits the adoption of better strategies to prevent HF development in chronically infarcted individuals.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900010
Editor:  Associação Brasileira de Divulgação Científica
Relação:  10.1590/S0100-879X2011007500096
Formato:  text/html
Fonte:  Brazilian Journal of Medical and Biological Research v.44 n.9 2011
Direitos:  info:eu-repo/semantics/openAccess
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