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Provedor de dados:  BJMBR
País:  Brazil
Título:  Peritoneal and serum interleukin-18 levels are not increased in women with minimum or mild endometriosis
Autores:  Glitz,C.
Souza,C.A.
Rodini,G.P.
Genro,V.
Bilibio,J.P.
Senger,M.
Cunha-Filho,J.S.
Data:  2009-11-01
Ano:  2009
Palavras-chave:  Cytokines
Endometriosis
IL-18
Peritoneal fluid
Infertility
Resumo:  Interleukin-18 (IL-18) is a cytokine that belongs to the IL-1 family. Endometriosis is strongly associated with sub-fertility, and affects about 15% of women of reproductive age. IL-18 may favor the progression of endometriosis. The objective of the present study was to determine the concentration of IL-18 in the serum and peritoneal fluid of infertile women with endometriosis. Forty infertile and 25 fertile women were screened in a teaching hospital. Thirty-four infertile patients with minimal or mild endometriosis and 22 fertile controls were enrolled in the study. The primary outcome was the estimate of IL-18 levels and the secondary outcome was the correlation between serum and peritoneal levels of IL-18. There were no differences between the two groups regarding age, body mass index and levels of peritoneal fluid IL-18 (mean ± SD): 290.85 ± 173.02 pg/mL for infertile women vs 374.21 ± 330.15 pg/mL for controls; or serum IL-18: 391.07 ± 119.71 pg/mL for infertile women vs 373.42 ± 129.11 pg/mL for controls. However, a positive association was found between serum and peritoneal IL-18 levels in patients with endometriosis: r = 0.794, P = 0.0001. All measurements were carried out at the same time by the Human IL-18 Immuno Assay ELISA kit (MBL Co. Ltd., Japan). The present study did not find evidence supporting the hypothesis that IL-18 levels are associated with infertility in women with minimal and mild endometriosis, although a positive correlation was detected in these women between peritoneal and serum levels of IL-18.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001100007
Editor:  Associação Brasileira de Divulgação Científica
Relação:  10.1590/S0100-879X2009001100007
Formato:  text/html
Fonte:  Brazilian Journal of Medical and Biological Research v.42 n.11 2009
Direitos:  info:eu-repo/semantics/openAccess
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