| Registro completo |
| Provedor de dados: |
BJMBR
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| País: |
Brazil
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| Título: |
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg
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| Autores: |
Giachini,F.R.
Lima,V.V.
Hannan,J.L.
Carneiro,F.S.
Webb,R.C.
Tostes,R.C.
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| Data: |
2011-11-01
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| Ano: |
2011
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| Palavras-chave: |
Ca2+ release-activated Ca2+ channel
Sarcoplasmic reticulum
Intracellular Ca2+ store
Ca2+ influx
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| Resumo: |
Highly efficient mechanisms regulate intracellular calcium (Ca2+) levels. The recent discovery of new components linking intracellular Ca2+ stores to plasma membrane Ca2+ entry channels has brought new insight into the understanding of Ca2+ homeostasis. Stromal interaction molecule 1 (STIM1) was identified as a Ca2+ sensor essential for Ca2+ store depletion-triggered Ca2+ influx. Orai1 was recognized as being an essential component for the Ca2+ release-activated Ca2+ (CRAC) channel. Together, these proteins participate in store-operated Ca2+ channel function. Defective regulation of intracellular Ca2+ is a hallmark of several diseases. In this review, we focus on Ca2+ regulation by the STIM1/Orai1 pathway and review evidence that implicates STIM1/Orai1 in several pathological conditions including cardiovascular and pulmonary diseases, among others.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011001100002
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| Editor: |
Associação Brasileira de Divulgação Científica
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| Relação: |
10.1590/S0100-879X2011007500133
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Medical and Biological Research v.44 n.11 2011
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| Direitos: |
info:eu-repo/semantics/openAccess
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