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Provedor de dados:  BJMBR
País:  Brazil
Título:  Evidence that blood pressure remains under the control of arterial baroreceptors in renal hypertensive rats
Autores:  Trindade Jr.,A.S.
Moreira,E.D.
Silva,G.J.J.
Krieger,E.M.
Data:  2009-10-01
Ano:  2009
Palavras-chave:  Arterial baroreceptor
Renal hypertension
Sinoaortic denervation
Aortic depressor nerve
Electrical stimul
Resumo:  The purpose of the present study was to determine the range of the influence of the baroreflex on blood pressure in chronic renal hypertensive rats. Supramaximal electrical stimulation of the aortic depressor nerve and section of the baroreceptor nerves (sinoaortic denervation) were used to obtain a global analysis of the baroreceptor-sympathetic reflex in normotensive control and in chronic (2 months) 1-kidney, 1-clip hypertensive rats. The fall in blood pressure produced by electrical baroreceptor stimulation was greater in renal hypertensive rats than in normotensive controls (right nerve: -47 ± 8 vs -23 ± 4 mmHg; left nerve: -51 ± 7 vs -30 ± 4 mmHg; and both right and left nerves: -50 ± 8 vs -30 ± 4 mmHg; P < 0.05). Furthermore, the increase in blood pressure level produced by baroreceptor denervation in chronic renal hypertensive rats was similar to that observed in control animals 2-5 h (control: 163 ± 5 vs 121 ± 1 mmHg; 1K-1C: 203 ± 7 vs 170 ± 5 mmHg; P < 0.05) and 24 h (control: 149 ± 3 vs 121 ± 1 mmHg; 1K-1C: 198 ± 8 vs 170 ± 5 mmHg; P < 0.05) after sinoaortic denervation. Taken together, these data indicate that the central and peripheral components of the baroreflex are acting efficiently at higher arterial pressure in renal hypertensive rats when the aortic nerve is maximally stimulated or the activity is abolished.
Tipo:  Info:eu-repo/semantics/other
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001000013
Editor:  Associação Brasileira de Divulgação Científica
Relação:  10.1590/S0100-879X2009001000013
Formato:  text/html
Fonte:  Brazilian Journal of Medical and Biological Research v.42 n.10 2009
Direitos:  info:eu-repo/semantics/openAccess
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