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Provedor de dados:  BJMBR
País:  Brazil
Título:  Effects of exercise training on autonomic and myocardial dysfunction in streptozotocin-diabetic rats
Autores:  De Angelis,K.L.D.
Oliveira,A.R.
Dall'Ago,P.
Peixoto,L.R.A.
Gadonski,G.
Lacchini,S.
Fernandes,T.G.
Irigoyen,M.C.
Data:  2000-06-01
Ano:  2000
Palavras-chave:  Experimental diabetes
Exercise training
Arterial pressure
Autonomic control
Myocardial contractility
Resumo:  Several investigators have demonstrated that diabetes is associated with autonomic and myocardial dysfunction. Exercise training is an efficient non-pharmacological treatment for cardiac and metabolic diseases. The aim of the present study was to investigate the effects of exercise training on hemodynamic and autonomic diabetic dysfunction. After 1 week of diabetes induction (streptozotocin, 50 mg/kg, iv), male Wistar rats (222 ± 5 g, N = 18) were submitted to exercise training for 10 weeks on a treadmill. Arterial pressure signals were obtained and processed with a data acquisition system. Autonomic function and intrinsic heart rate were studied by injecting methylatropine and propranolol. Left ventricular function was assessed in hearts perfused in vitro by the Langendorff technique. Diabetes (D) bradycardia and hypotension (D: 279 ± 9 bpm and 91 ± 4 mmHg vs 315 ± 11 bpm and 111 ± 4 mmHg in controls, C) were attenuated by training (TD: 305 ± 7 bpm and 100 ± 4 mmHg). Vagal tonus was decreased in the diabetic groups and sympathetic tonus was similar in all animals. Intrinsic heart rate was lower in D (284 ± 11 bpm) compared to C and TD (390 ± 8 and 342 ± 14 bpm, respectively). Peak systolic pressure developed at different pressures was similar for all groups, but +dP/dt max was decreased and -dP/dt max was increased in D. In conclusion, exercise training reversed hypotension and bradycardia and improved myocardial function in diabetic rats. These changes represent an adaptive response to the demands of training, supporting a positive role of physical activity in the management of diabetes.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000600004
Editor:  Associação Brasileira de Divulgação Científica
Relação:  10.1590/S0100-879X2000000600004
Formato:  text/html
Fonte:  Brazilian Journal of Medical and Biological Research v.33 n.6 2000
Direitos:  info:eu-repo/semantics/openAccess
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