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Provedor de dados:  BJMBR
País:  Brazil
Título:  Safety and efficacy of regional citrate anticoagulation in continuous blood purification treatment of patients with multiple organ dysfunction syndrome
Autores:  Tuerdi,B.
Zuo,L.
Sun,H.
Wang,K.
Wang,Z.
Li,G.
Data:  2018-01-01
Ano:  2018
Palavras-chave:  Multiple organ dysfunction syndrome
Continuous blood purification
Blood coagulation function
Sodium citrate
Resumo:  The aim of this study was to discuss the safety and efficacy of regional citrate anticoagulation (RCA) on continuous blood purification (CBP) during the treatment of multiple organ dysfunction syndrome (MODS). Thirty-five patients with MODS were divided into two groups: the local citrate anticoagulation (RCA) group, and the heparin-free blood purification (hfBP) group. The MODS severity was assessed according to Marshall’s MODS score criteria. Blood coagulation indicators, blood pressure, filter lifespan, filter replacement frequency, anticoagulation indicators, and main metabolic and electrolyte indicators were analyzed and compared between RCA and hfBP groups. RCA resulted in lower blood pressure than hfBP. The filter efficacy in RCA treatment was longer than in the hfBP group. The blood clearance of creatine, blood urea nitrogen and uric acid was better in the RCA group. RCA also led to higher pH than hfBP. Neither treatment resulted in severe bleeding events. In addition, MODS score was positively correlated with prothrombin time and activated partial thromboplastin time but negatively correlated with platelet concentration. RCA is a safer and more effective method in CBP treatment; however, it could also lead to low blood pressure and blood alkalosis.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000100605
Editor:  Associação Brasileira de Divulgação Científica
Relação:  10.1590/1414-431x20176378
Formato:  text/html
Fonte:  Brazilian Journal of Medical and Biological Research v.51 n.1 2018
Direitos:  info:eu-repo/semantics/openAccess
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