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Provedor de dados:  BJMBR
País:  Brazil
Título:  Ischemia and fibrosis: the risk mechanisms of hypertensive heart disease
Autores:  Frohlich,E.D.
Data:  2000-06-01
Ano:  2000
Palavras-chave:  Left ventricular hypertrophy
LVH
Risk factor
Myocardial ischemia
Ventricular fibrosis
Resumo:  Mechanisms underlying risk associated with hypertensive heart disease (HHD) and left ventricular hypertrophy (LVH) are discussed in this report and provide a rationale for understanding this very common and important cause of death from hypertension and its complications. Emphasized are impaired coronary hemodynamics, endothelial dysfunction, and ventricular fibrosis from increased collagen deposition intramurally and perivascularly. Each is exacerbated by aging and, perhaps, also by increased dietary salt intake. These functional and structural changes promote further endothelial dysfunction, altered coronary hemodynamics, and diastolic as well as systolic ventricular contractile function in HHD. The clinical endpoints of HHD include angina pectoris (with or without atherosclerosis of the epicardial coronary arteries), myocardial infarction, cardiac failure, lethal dysrhythmias, and sudden death. The major concept to be derived from these alterations is that not all that is clinically recognized as LVH is true myocytic hypertrophy and structural remodeling. Other major co-morbid changes occur that serve to increase cardiovascular risk including impaired coronary hemodynamics, endothelial dysfunction, and ventricular fibrosis.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000600010
Editor:  Associação Brasileira de Divulgação Científica
Relação:  10.1590/S0100-879X2000000600010
Formato:  text/html
Fonte:  Brazilian Journal of Medical and Biological Research v.33 n.6 2000
Direitos:  info:eu-repo/semantics/openAccess
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