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Provedor de dados:  BJMBR
País:  Brazil
Título:  Overexpression of myeloid differentiation protein 88 in mice induces mild cardiac dysfunction, but no deficit in heart morphology
Autores:  Chen,W.
Huang,Z.
Jiang,X.
Li,C.
Gao,X.
Data:  2016-01-01
Ano:  2016
Palavras-chave:  Cardiac dysfunction
Cardiac remodeling
Transgenic mice
Myeloid differentiation protein 88
Resumo:  Cardiac remodeling involves changes in heart shape, size, structure, and function after injury to the myocardium. The proinflammatory adaptor protein myeloid differentiation protein 88 (MyD88) contributes to cardiac remodeling. To investigate whether excessive MyD88 levels initiate spontaneous cardiac remodeling at the whole-organism level, we generated a transgenic MyD88 mouse model with a cardiac-specific promoter. MyD88 mice (male, 20-30 g, n=∼80) were born at the expected Mendelian ratio and demonstrated similar morphology of the heart and cardiomyocytes with that of wild-type controls. Although heart weight was unaffected, cardiac contractility of MyD88 hearts was mildly reduced, as shown by echocardiographic examination, compared with wild-type controls. Moreover, the cardiac dysfunction phenotype was associated with elevation of ANF and BNP expression. Collectively, our data provide novel evidence of the critical role of balanced MyD88 signaling in maintaining physiological function in the adult heart.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000100605
Editor:  Associação Brasileira de Divulgação Científica
Relação:  10.1590/1414-431x20154794
Formato:  text/html
Fonte:  Brazilian Journal of Medical and Biological Research v.49 n.1 2016
Direitos:  info:eu-repo/semantics/openAccess
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