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Provedor de dados:  56
País:  Brazil
Título:  Sleep deprivation reduces the lymphocyte count in a non-obese mouse model of type 1 diabetes mellitus
Autores:  Ruiz,F.S.
Andersen,M.L.
Zager,A.
Martins,R.C.S.
Tufik,S.
Data:  2007-05-01
Ano:  2007
Palavras-chave:  Sleep deprivation
Stress
Lymphopenia
Diabetes
Non-obese diabetic mouse
Swiss mice
Resumo:  The objective of the present study was to determine whether sleep deprivation (SD) would promote changes in lymphocyte numbers in a type 1 diabetes model (non-obese diabetic, NOD, mouse strain) and to determine whether SD would affect female and male NOD compared to Swiss mice. The number of lymphocytes in peripheral blood after 24 and 96 h of SD (by multiple platform method) or equivalent period of time in home-cage controls was examined prior to the onset of diabetes. SD for 96 h significantly reduced lymphocytes in male Swiss mice compared to control (8.6 ± 2.1 vs 4.1 ± 0.7 10³/µL; P < 0.02). In male NOD animals, 24- and 96-h SD caused a significant decrease of lymphocytes compared to control (4.4 ± 0.3 vs 1.6 ± 0.5; P < 0.001 and 4.4 ± 0.3 vs 0.9 ± 0.1 10³/µL; P < 0.00001, respectively). Both 24- and 96-h SD induced a reduction in the number of lymphocytes in female Swiss (7.5 ± 0.5 vs 4.5 ± 0.5, 4.4 ± 0.6 10³/µL; P < 0.001, respectively) and NOD mice (4 ± 0.6 vs 1.8 ± 0.2, 1.2 ± 0.4 10³/µL; P < 0.01, respectively) compared to the respective controls. Loss of sleep induced lymphopenia in peripheral blood in both genders and strains used. Since many cases of autoimmunity present reduced numbers of lymphocytes and, in this study, it was more evident in the NOD strain, our results suggest that SD should be considered a risk factor in the onset of autoimmune disorders.
Tipo:  Info:eu-repo/semantics/other
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000500005
Editor:  Associação Brasileira de Divulgação Científica
Relação:  10.1590/S0100-879X2006005000086
Formato:  text/html
Fonte:  Brazilian Journal of Medical and Biological Research v.40 n.5 2007
Direitos:  info:eu-repo/semantics/openAccess
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