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Provedor de dados:  BJMBR
País:  Brazil
Título:  Functional evidence that the central renin-angiotensin system plays a role in the pressor response induced by central injection of carbachol
Data:  1997-04-01
Ano:  1997
Palavras-chave:  Pressor response
Central angiotensin
Carbachol
Resumo:  We investigated the effects of losartan, an AT1-receptor blocker, and ramipril, a converting enzyme inhibitor, on the pressor response induced by angiotensin II (ANG II) and carbachol (a cholinergic receptor agonist). Male Holtzman rats (250-300 g) with a stainless steel cannula implanted into the lateral ventricle (LV) were used. The injection of losartan (50 nmol/1 µl) into the LV blocked the pressor response induced by ANG II (12 ng/1 µl) and carbachol (2 nmol/1 µl). After injection of ANG II and carbachol into the LV, mean arterial pressure (MAP) increased to 31 ± 1 and 28 ± 2 mmHg, respectively. Previous injection of losartan abolished the increase in MAP induced by ANG II and carbachol into the LV (2 ± 1 and 5 ± 2 mmHg, respectively). The injection of ramipril (12 ng/1 µl) prior to carbachol blocked the pressor effect of carbachol to 7 ± 3 mmHg. These results suggest an interaction between central cholinergic pathways and the angiotensinergic system in the regulation of arterial blood pressure
Tipo:  Info:eu-repo/semantics/other
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000400010
Editor:  Associação Brasileira de Divulgação Científica
Relação:  10.1590/S0100-879X1997000400010
Formato:  text/html
Fonte:  Brazilian Journal of Medical and Biological Research v.30 n.4 1997
Direitos:  info:eu-repo/semantics/openAccess
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