| Registro completo |
| Provedor de dados: |
BJMBR
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| País: |
Brazil
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| Título: |
Disseminated Langerhans' cell histiocytosis and massive protein-losing enteropathy
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| Autores: |
Santos-Machado,T.M.
Cristófani,L.M.
Almeida,M.T.A.
Maluf,P.T.
Costa,P.A.
Pereira,M.A.
Brito,J.L.B.C.
Odone-Filho,V.
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| Data: |
1999-09-01
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| Ano: |
1999
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| Palavras-chave: |
Langerhans' cell histiocytosis
Histiocytosis X
Gastrointestinal involvement
Protein-losing enteropathy
Hypoalbuminemia
Cr51-labeled albumin test
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| Resumo: |
Symptomatic involvement of the gastrointestinal (GI) tract as a prominent symptom in Langerhans' cell histiocytosis (LCH) is uncommon, occurring in less than 1 to 5% of all cases, even when the disease is in its disseminated form. Up to now, there have been reports of 18 cases of LCH with GI manifestations, including our 2 cases, with diarrhea (77.7%), protein-losing enteropathy (33.3%) and bloody stool being the most frequent findings. The authors present two patients with severe diarrhea and refractory hypoalbuminemia, and with the protein-losing enteropathy documented by Cr51-labeled albumin studies. A review of the literature indicated that the presence of GI symptoms is often associated with systemic disease as well as with poor prognosis, mainly under 2 years of age. Radioisotopes are useful for documenting protein loss in several diseases with high specificity and sensitivity, and their utilization in the cases reviewed here permitted diagnoses in 6 children, as well as improved therapeutic management.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000900007
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| Editor: |
Associação Brasileira de Divulgação Científica
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| Relação: |
10.1590/S0100-879X1999000900007
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Medical and Biological Research v.32 n.9 1999
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| Direitos: |
info:eu-repo/semantics/openAccess
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