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Provedor de dados:  BJMBR
País:  Brazil
Título:  Montelukast reduces seizures in pentylenetetrazol-kindled mice
Autores:  Fleck,J.
Temp,F.R.
Marafiga,J.R.
Jesse,A.C.
Milanesi,L.H.
Rambo,L.M.
Mello,C.F.
Data:  2016-01-01
Ano:  2016
Palavras-chave:  Montelukast
CysLT1R
CysLT2R
Seizure
PTZ
Kindling
Resumo:  Cysteinyl leukotrienes (CysLTs) have been implicated in seizures and kindling; however, the effect of CysLT receptor antagonists on seizure frequency in kindled animals and changes in CysLT receptor expression after pentylenetetrazol (PTZ)-induced kindling have not been investigated. In this study, we evaluated whether the CysLT1 inverse agonist montelukast, and a classical anticonvulsant, phenobarbital, were able to reduce seizures in PTZ-kindled mice and alter CysLT receptor expression. Montelukast (10 mg/kg, sc) and phenobarbital (20 mg/kg, sc) increased the latency to generalized seizures in kindled mice. Montelukast increased CysLT1immunoreactivity only in non-kindled, PTZ-challenged mice. Interestingly, PTZ challenge decreased CysLT2 immunoreactivity only in kindled mice. CysLT1 antagonists appear to emerge as a promising adjunctive treatment for refractory seizures. Nevertheless, additional studies are necessary to evaluate the clinical implications of this research.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000400602
Editor:  Associação Brasileira de Divulgação Científica
Relação:  10.1590/1414-431X20155031
Formato:  text/html
Fonte:  Brazilian Journal of Medical and Biological Research v.49 n.4 2016
Direitos:  info:eu-repo/semantics/openAccess
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