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Provedor de dados:  BJMBR
País:  Brazil
Título:  Influence of antihypertensive drugs on aortic and coronary effects of Ang-(1-7) in pressure-overloaded rats
Autores:  Nunes,A.D.C.
Souza,A.P.S.
Macedo,L.M.
Alves,P.H.
Pedrino,G.R.
Colugnati,D.B.
Mendes,E.P.
Santos,R.A.S.
Castro,C.H.
Data:  2017-01-01
Ano:  2017
Palavras-chave:  Angiotensin-(1-7)
Renin-angiotensin system
Coronary artery
Antihypertensive drugs
Cardiac hypertrophy
Resumo:  This study investigated the influence of antihypertensive drugs, such as angiotensin-converting enzyme inhibitors (ACEIs), AT1 receptor blockers (ARBs), voltage-gated L-type calcium channel blockers, and mineralocorticoid receptor antagonists (MRAs), on the effects of angiotensin-(1-7) [Ang-(1-7)] on aorta and coronary arteries from pressure-overloaded rats. Pressure overload was induced by abdominal aortic banding (AB). To evaluate the role of antihypertensive drugs on the effect of Ang-(1-7), AB male Wistar rats weighing 250–300 g were treated with vehicle or low doses (5 mg·kg-1·day-1, gavage) of losartan, captopril, amlodipine, or spironolactone. Isolated aortic rings and isolated perfused hearts under constant flow were used to evaluate the effect of Ang-(1-7) in thoracic aorta and coronary arteries, respectively. Ang-(1-7) induced a significant relaxation in the aorta of sham animals, but this effect was reduced in the aortas of AB rats. Chronic treatments with losartan, captopril or amlodipine, but not with spironolactone, restored the Ang-(1-7)-induced aorta relaxation in AB rats. The coronary vasodilatation evoked by Ang-(1-7) in sham rats was blunted in hypertrophic rats. Only the treatment with losartan restored the coronary vasodilatory effect of Ang-(1-7) in AB rat hearts. These data support a beneficial vascular effect of an association of Ang-(1-7) and some antihypertensive drugs. Thus, this association may have potential as a new therapeutic strategy for cardiovascular diseases.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000400604
Editor:  Associação Brasileira de Divulgação Científica
Relação:  10.1590/1414-431x20165520
Formato:  text/html
Fonte:  Brazilian Journal of Medical and Biological Research v.50 n.4 2017
Direitos:  info:eu-repo/semantics/openAccess
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