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Provedor de dados:  BJMBR
País:  Brazil
Título:  Overexpression of Fc receptor-like 1 associated with B-cell activation during hepatitis B virus infection
Autores:  Wang,Ke
Pei,Hao
Huang,Biao
Yang,Run-Lin
Wu,Hang-Yuan
Zhu,Xue
Zhu,Lan
Data:  2012-12-01
Ano:  2012
Palavras-chave:  Hepatitis B virus
B-cell activation
Fc receptor-like 1
Gene expression
Resumo:  The role of B cells in the pathogenesis of hepatitis B virus (HBV) infection has not been explored in depth. In the present study, the activation status of B cells from peripheral blood of healthy controls (N = 20) and patients with acute hepatitis B (AHB, N = 15) or chronic hepatitis B (CHB, N = 30) was evaluated by measuring the expression levels of B-cell activation markers CD69 and CD86, using quantitative real-time PCR and flow cytometry. Moreover, the potential mechanism underlying B-cell activation during HBV infection was further investigated by analyzing the expression profile of FCRL1, an intrinsic activation molecule of B cells. An elevation in the levels of B-cell activation markers including CD69 and CD86 was observed in the AHB patients (44.31 ± 9.27, 27.64 ± 9.26%) compared to CHB patients (30.35 ± 11.27, 18.41 ± 6.56%, P < 0.05), which was still higher than healthy controls (12.23 ± 7.84, 8.22 ± 3.43%, P < 0.05). Furthermore, the expression of FCRL1 was found to be similar to B-cell activation markers, which was highest in AHB patients (70.15 ± 17.11%), lowest in healthy donors (36.32 ± 9.98%, P < 0.05) and half-way between these levels in patients with CHB (55.17 ± 12.03%, P < 0.05). The results were positively associated with aberrant B-cell activation. These data suggest that B cells can play a role in HBV infection, and therefore more effort should be devoted to exploring their functions.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001200002
Editor:  Associação Brasileira de Divulgação Científica
Relação:  10.1590/S0100-879X2012007500130
Formato:  text/html
Fonte:  Brazilian Journal of Medical and Biological Research v.45 n.12 2012
Direitos:  info:eu-repo/semantics/openAccess
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