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Provedor de dados:  BJMBR
País:  Brazil
Título:  Experimental models in vaccine research: malaria and leishmaniasis
Autores:  Teixeira,C.
Data:  2013-02-01
Ano:  2013
Palavras-chave:  Human vaccines
Animal models
Resumo:  Animal models have a long history of being useful tools, not only to test and select vaccines, but also to help understand the elaborate details of the immune response that follows infection. Different models have been extensively used to investigate putative immunological correlates of protection against parasitic diseases that are important to reach a successful vaccine. The greatest challenge has been the improvement and adaptation of these models to reflect the reality of human disease and the screening of vaccine candidates capable of overcoming the challenge of natural transmission. This review will discuss the advantages and challenges of using experimental animal models for vaccine development and how the knowledge achieved can be extrapolated to human disease by looking into two important parasitic diseases: malaria and leishmaniasis.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Editor:  Associação Brasileira de Divulgação Científica
Relação:  10.1590/1414-431X20122460
Formato:  text/html
Fonte:  Brazilian Journal of Medical and Biological Research v.46 n.2 2013
Direitos:  info:eu-repo/semantics/openAccess

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