| Registro completo |
| Provedor de dados: |
BJMBR
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| País: |
Brazil
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| Título: |
Toxicity to sea urchin egg development of the quinone fraction obtained from Auxemma oncocalyx
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| Autores: |
Costa-Lotufo,L.V.
Ferreira,M.A.D.
Lemos,T.L.G.
Pessoa,O.D.L.
Viana,G.S.B.
Cunha,G.M.A.
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| Data: |
2002-08-01
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| Ano: |
2002
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| Palavras-chave: |
Auxemma oncocalyx
Quinones
Sea urchin eggs
Oncocalyxone A
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| Resumo: |
Auxemma oncocalyx Taub. belongs to the Boraginaceae family and is native to the Brazilian northeast where it is known as "pau-branco". We investigated the ability of the water soluble fraction isolated from the heartwood of A. oncocalyx to inhibit sea urchin egg development. This fraction contains about 80% oncocalyxone A (quinone fraction), a compound known to possess strong cytotoxic and antitumor activities. In fact, the quinone fraction inhibited cleavage in a dose-dependent manner [IC50 of 18.4 (12.4-27.2) µg/ml, N = 6], and destroyed the embryos in the blastula stage [IC50 of 16.2 (13.7-19.2) µg/ml, N = 6]. We suggest that this activity is due to the presence of oncocalyxone A. In fact, these quinones present in A. oncocalyx extract have strong toxicity related to their antimitotic activity.
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| Tipo: |
Info:eu-repo/semantics/other
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000800010
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| Editor: |
Associação Brasileira de Divulgação Científica
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| Relação: |
10.1590/S0100-879X2002000800010
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Medical and Biological Research v.35 n.8 2002
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| Direitos: |
info:eu-repo/semantics/openAccess
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