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Provedor de dados:  BJMBR
País:  Brazil
Título:  Do endogenous opioids and nitric oxide participate in the anticonvulsant action of dipyrone?
Autores:  Reis,G.M.L.
Doretto,M.C.
Duarte,I.D.G.
Tatsuo,M.A.K.F.
Data:  2003-09-01
Ano:  2003
Palavras-chave:  Epilepsy
Dipyrone
Audiogenic seizures
Electroshock
Nitric oxide
Opiates
Resumo:  It was previously reported that systemic administration of dipyrone inhibited the tonic component of generalized tonic-clonic seizures in both the electroshock and the audiogenic seizure models. The aim of the present study was to investigate the mechanisms involved in the anticonvulsant action of dipyrone by assessing the role of nitric oxide and opioids in the electroshock (female 60- to 90-day-old Wistar rats, N = 5-11) and audiogenic seizure (female 60- to 90-day-old Wistar audiogenic rats, N = 5-11) models of epilepsy. Naloxone (5 mg/kg, sc) significantly reversed the anticonvulsant effect of dipyrone in rats submitted to the induction of audiogenic seizures (ANOVA/Bonferroni's test), suggesting the involvement of opioid peptides in this action. In the electroshock model no reversal of the anticonvulsant effect of dipyrone by naloxone (5 mg/kg, sc) was demonstrable. The acute (120 mg/kg, ip) and chronic (25 mg/kg, ip, twice a day/4 days) administration of L-NOARG did not reverse the anticonvulsant action of dipyrone in the audiogenic seizure model, suggesting that the nitric oxide pathway does not participate in such effect. Indomethacin (10, 20 and 30 mg/kg, ip) used for comparison had no anticonvulsant effect in the audiogenic seizure model. In conclusion, opioid peptides but not nitric oxide seem to be involved in the anticonvulsant action of dipyrone in audiogenic seizures.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000900018
Editor:  Associação Brasileira de Divulgação Científica
Relação:  10.1590/S0100-879X2003000900018
Formato:  text/html
Fonte:  Brazilian Journal of Medical and Biological Research v.36 n.9 2003
Direitos:  info:eu-repo/semantics/openAccess
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