| Registro completo |
| Provedor de dados: |
56
|
| País: |
Brazil
|
| Título: |
Low ethanol consumption increases insulin sensitivity in Wistar rats
|
| Autores: |
Furuya,D.T.
Binsack,R.
Machado,U.F.
|
| Data: |
2003-01-01
|
| Ano: |
2003
|
| Palavras-chave: |
Insulin sensitivity
Ethanol
Liver glycogen
Low ethanol consumption
|
| Resumo: |
Several human studies suggest that light-to-moderate alcohol consumption is associated with enhanced insulin sensitivity, but these studies are not free of conflicting results. To determine if ethanol-enhanced insulin sensitivity could be demonstrated in an animal model, male Wistar rats were fed a standard chow diet and received drinking water without (control) or with different ethanol concentrations (0.5, 1.5, 3, 4.5 and 7%, v/v) for 4 weeks ad libitum. Then, an intravenous insulin tolerance test (IVITT) was performed to determine insulin sensitivity. Among the ethanol groups, only the 3% ethanol group showed an increase in insulin sensitivity based on the increase of the plasma glucose disappearance rate in the IVITT (30%, P<0.05). In addition, an intravenous glucose tolerance test (IVGTT) was performed in control and 3% ethanol animals. Insulin sensitivity was confirmed in 3% ethanol rats based on the reduction of insulin secretion in the IVGTT (35%, P<0.05), despite the same glucose profile. Additionally, the 3% ethanol treatment did not impair body weight gain or plasma aspartate aminotransferase and alanine aminotransferase activities. Thus, the present study established that 3% ethanol in the drinking water for 4 weeks in normal rats is a model of increased insulin sensitivity, which can be used for further investigations of the mechanisms involved.
|
| Tipo: |
Info:eu-repo/semantics/other
|
| Idioma: |
Inglês
|
| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000100017
|
| Editor: |
Associação Brasileira de Divulgação Científica
|
| Relação: |
10.1590/S0100-879X2003000100017
|
| Formato: |
text/html
|
| Fonte: |
Brazilian Journal of Medical and Biological Research v.36 n.1 2003
|
| Direitos: |
info:eu-repo/semantics/openAccess
|
|
