| Registro completo |
| Provedor de dados: |
BJM
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| País: |
Brazil
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| Título: |
Synergistic effects of tacrolimus and azole antifungal compounds in fluconazole-susceptible and fluconazole-resistant Candida glabrata isolates
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| Autores: |
Denardi,Laura Bedin
Mario,Débora Alves Nunes
Loreto,Érico Silva
Santurio,Janio Morais
Alves,Sydney Hartz
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| Data: |
2015-03-01
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| Ano: |
2015
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| Palavras-chave: |
Candida glabrata
Azole resistance
FK506
Combination therapy
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| Resumo: |
In vitro interaction between tacrolimus (FK506) and four azoles (fluconazole, ketoconazole, itraconazole and voriconazole) against thirty clinical isolates of both fluconazole susceptible and -resistant Candida glabrata were evaluated by the checkerboard microdilution method. Synergistic, indifferent or antagonism interactions were found for combinations of the antifungal agents and FK506. A larger synergistic effect was observed for the combinations of FK506 with itraconazole and voriconazole (43%), followed by that of the combination with ketoconazole (37%), against fluconazole-susceptible isolates. For fluconazole-resistant C. glabrata, a higher synergistic effect was obtained from FK506 combined with ketoconazole (77%), itraconazole (73%), voriconazole (63%) and fluconazole (60%). The synergisms that we observed in vitro, notably against fluconazole-resistant C. glabrata isolates, are promising and warrant further analysis of their applications in experimental in vivo studies.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822015000100125
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| Editor: |
Sociedade Brasileira de Microbiologia
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| Relação: |
10.1590/S1517-838246120120442
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Microbiology v.46 n.1 2015
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| Direitos: |
info:eu-repo/semantics/openAccess
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