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Provedor de dados:  BJM
País:  Brazil
Título:  Molecular epidemiology of Shigella spp strains isolated in two different metropolitam areas of southeast Brazil
Autores:  Angelini,Michelle
Stehling,Eliana Guedes
Moretti,Maria Luiza
Silveira,Wanderley Dias da
Data:  2009-09-01
Ano:  2009
Palavras-chave:  Shigella sonnei
Shigella flexneri
Resumo:  Shigella spp., the human pathogen responsible for shigellosis, is highly infectious even at low levels. The incidence rate of shigellosis varies with geographical distribution, location human development index, and age groups, being higher among children aged under 5 years. In Brazil, a few works indicate that shigellosis cases are underestimated, with S. flexneri and S. sonnei strains being the major agents responsible for the shigellosis cases. The present study used pulsed field gel electrophoresis (PFGE) to investigate the molecular epidemiology of 119 strains of S. sonnei and S. flexneri isolated from shigellosis cases that occurred in the metropolitan areas of Ribeirão Preto and Campinas Cities, São Paulo Sate, southeast Brazil. The results indicated (i) the existence of just a few strain clusters for both species, but with genotype variability with either a high speed of genetic change or constant introduction of several genotypes, considering the intense migration to these two metropolitan areas, and (ii) the prevalence of specific genotypes in each geographical area, which suggests the successful adaptation of some genotypes to the local environmental conditions. Our results indicate the need of more efficacious sanitary barriers to prevent Shigella spp. outbreaks and epidemics.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Editor:  Sociedade Brasileira de Microbiologia
Relação:  10.1590/S1517-83822009000300034
Formato:  text/html
Fonte:  Brazilian Journal of Microbiology v.40 n.3 2009
Direitos:  info:eu-repo/semantics/openAccess

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