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Provedor de dados:  BJM
País:  Brazil
Título:  Candida albicans: genotyping methods and clade related phenotypic characteristics
Autores:  Lyon,Juliana P.
Moraes,Karen C.M.
Moreira,Leonardo M.
Resende,Maria Aparecida de
Data:  2010-12-01
Ano:  2010
Palavras-chave:  Candida albicans
Clonal reproduction
Genotyping systems
Phenotypic characteristics
Resumo:  Several molecular methods, such as Southern blotting hybridization, Multilocus Sequence Typing, and DNA microsatellite analysis, have been employed to genotype Candida albicans. The genotype analysis allows to group strains in clades, that is, a group composed of one ancestor and its descendants. These genotype studies demonstrate that clades distribution is influenced by geographic area as well as that antifungal resistance is associated with particular clades. These findings suggested that C. albicans reproduces mainly in a clonal manner, with certain degree of DNA microevolution. Additionally, virulence factors and site of isolation have also been associated with clade specificity. The present article is a brief review about the methods used for Candida genotyping and the correlated clade systems established. Special emphasis is given to Ca3 hybridization, MLST, and Microsatellites. The present work is also focused on the phenotypic and physiological traits associated with Candida clades.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Editor:  Sociedade Brasileira de Microbiologia
Relação:  10.1590/S1517-83822010000400003
Formato:  text/html
Fonte:  Brazilian Journal of Microbiology v.41 n.4 2010
Direitos:  info:eu-repo/semantics/openAccess

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