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Provedor de dados:  BJM
País:  Brazil
Título:  Genotoxicity of the cyclo-oxygenase-inhibitor sulindac sulfide in the filamentous fungus Aspergillus nidulans
Autores:  Franco,Claudinéia Conationi da Silva
Miyamoto,Claudia Tiemi
Sant'Anna,Juliane Rocha de
Castro-Prado,Marialba Avezum Alves de
Data:  2007-09-01
Ano:  2007
Palavras-chave:  Antineoplastic agents
Mitotic crossing-over
Secondary malignances
Resumo:  Sulindac sulfide is a non-steroidal anti-inflammatory drug (NSAID) with chemopreventive effect on human cancer cells. Due to the involvement of the somatic recombination in the carcinogenic process, sulindac sulfide's recombinogenic potential was evaluated by the Homozygotization Index (HI) in the filamentous fungus Aspergillus nidulans. The drug's recombinogenic potential was evaluated by its capacity to induce homozygosis of recessive genes from heterozygous diploid cells. Sulindac sulfide at 175 and 350 µM concentrations induced mitotic recombination in A. nidulans diploid cells, with HI values for genetic markers higher than 2.0, and significantly different from control HI values. The recombinogenic effect of NSAID was related to the induction of DNA strand breaks and cell cycle alterations. Sulindac sulfide's carcinogenic potential was also discussed.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822007000300009
Editor:  Sociedade Brasileira de Microbiologia
Relação:  10.1590/S1517-83822007000300009
Formato:  text/html
Fonte:  Brazilian Journal of Microbiology v.38 n.3 2007
Direitos:  info:eu-repo/semantics/openAccess
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