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Provedor de dados:  BJM
País:  Brazil
Título:  Activation of the alternative complement pathway in canine normal serum by Paracoccidioides brasiliensis
Autores:  Bianchini,A.A.C.
Petroni,T.F.
Fedatto,P.F.
Bianchini,R.R.
Venancio,E.J.
Itano,E.N.
Ono,M.A.
Data:  2009-06-01
Ano:  2009
Palavras-chave:  Paracoccidioidomycosis
Dog
Complement
Resumo:  The dimorphic fungus Paracoccidioides brasiliensis is the etiological agent of paracoccidioidomycosis, a human granulomatous disease. Recently the first case of natural disease in dogs was reported. The complement system is an important effector component of humoral immunity against infectious agents. Therefore, the aim of this study was to evaluate the activation of the dog alternative complement pathway by P. brasiliensis. Initially, the ability of erythrocytes of guinea pig, rabbit, sheep, chicken and swine to activate the dog alternative pathway was evaluated. The guinea pig erythrocytes showed the greatest capacity to activate dog alternative pathway. The alternative (AH50) hemolytic activity was evaluated in 27 serum samples from healthy dogs and the mean values were 87.2 AH50/ml. No significant differences were observed in relation to sex and age. The alternative pathway activation by P. brasiliensis was higher in serum samples from adult dogs when compared to puppies and aged dogs (p < 0.05). This is the first report of dog alternative complement pathway activation by P. brasiliensis and suggests that it may play a protective role in canine paracoccidioidomycosis.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822009000200005
Editor:  Sociedade Brasileira de Microbiologia
Relação:  10.1590/S1517-83822009000200005
Formato:  text/html
Fonte:  Brazilian Journal of Microbiology v.40 n.2 2009
Direitos:  info:eu-repo/semantics/openAccess
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