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Provedor de dados:  BJPS
País:  Brazil
Título:  Relationship between composition and organizational levels of nanostructured systems formed by Oleth 10 and PPG-5-Ceteth-20 for potential drug delivery
Autores:  Rissi,Nathalia Cristina
Guglielmi,Danila Aparecida Scatolin
Corrêa,Marcos Antônio
Chiavacci,Leila Aparecida
Data:  2014-09-01
Ano:  2014
Palavras-chave:  Ternary phase diagrams
Nanostructured systems
Small-angle X-ray scattering/profiles
Drugs/delivery systems
Resumo:  In this paper, nanostructured systems were developed, with the aid of ternary phase diagrams, from two surfactants, of differing degrees of lipophilicity (PPG-5-Ceteth-20 and the Oleth 10) and two oil phases (oleic acid and isopropyl myristate). It was observed that there were differences between the four resulting phase diagrams in the physical properties of the systems they represent. Thus, due to the capacity of Oleth 10 (as surfactant) and oleic acid (as the oil phase) to reduce interfacial tension, large regions of translucent systems were seen on the diagrams produced by them. By polarized light microscopy, it was possible to identify the isotropic and anisotropic properties of these systems, which were confirmed by small-angle X-ray scattering (SAXS) analysis. Furthermore, it was found that increasing the proportion of water in the formulations led to more highly organized structures, resulting in narrower and well defined SAXS peaks.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Editor:  Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação:  10.1590/S1984-82502014000300025
Formato:  text/html
Fonte:  Brazilian Journal of Pharmaceutical Sciences v.50 n.3 2014
Direitos:  info:eu-repo/semantics/openAccess

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