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Provedor de dados:  BJPS
País:  Brazil
Título:  Development of fast dispersing tablets of nebivolol: experimental and computational approaches to study formulation characteristics
Autores:  Jayaramu,Rajamma Abburu
Boregowda,Sateesha Shivally
Varma,Addanki Rahul Deva
Kalegowda,Chandan
Data:  2014-12-01
Ano:  2014
Palavras-chave:  Nebivolol/fast dispersing tablets
Simplex lattice design
Tablets/fast dispersing/swelling capacity
Tablets/fast dispersing/hydration capacity
Tablets/fast dispersing/disintegration time
Resumo:  Formulation of FDT (fast dispersing tablets) of nebivolol was optimized and evaluated using simplex lattice design (SLD). The influence of type and concentration of three disintegrants viz.,Ac-Di-Sol, Primojel and Polyplasdone XL on hardness, friability and disintegration time of tablet was studied. Response surface plot and the polynomial equations were used to evaluate influence of polymer on the tablet properties. Results were statistically analyzed using ANOVA, and a p < 0.05 was considered statistically significant. Results reveal that fibrous integrity and optimal degree of substitution in Primojel and Ac-Di-Sol are mainly responsible for the hardness of the tablet. Use of Polyplasdone in higher percentage in tablet formulation may result in high friability. Increase in concentration of Ac-Di-Sol increases the disintegration time but increased concentration of Primojel in the tablet formulation decreases the disintegration time. This is also evident from model terms for disintegration time with a high 'F' value of 14.69 and 'p' value of 0.0031 (<0.05). The reason could be that Primojel has higher swelling properties and an optimum hydration capacity, which favors fast disintegration of a tablet. In conclusion, careful selection of disintegrant for FDT could improve their properties. Use of Simplex Lattice Design for formulation development could simplify the formulation process and reduce the production cost.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400956
Editor:  Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação:  10.1590/S1984-82502014000400031
Formato:  text/html
Fonte:  Brazilian Journal of Pharmaceutical Sciences v.50 n.4 2014
Direitos:  info:eu-repo/semantics/openAccess
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