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Provedor de dados:  BJPS
País:  Brazil
Título:  Formulation and evaluation of bi-layer floating tablets of ziprasidone HCl and trihexyphenidyl HCl
Autores:  Dinakaran,Sathis Kumar
Data:  2011-09-01
Ano:  2011
Palavras-chave:  Bi-layer tablet
Ziprasidone HCl
Trihexyphenidyl HCl
Sustained release
Resumo:  The purpose of this research study was to establish ziprasidone HCl NR 40 mg and trihexyphenidyl HCl SR 4mg in the form of bi-layer sustained release floating tablets. The tablets were prepared using sodium HPMC K4M / HPMC K15M as bio-adhesive polymers and sodium bicarbonate acting as a floating layer. Tablets were evaluated based on different parameters such as thickness, hardness, friability, weight variation, in vitro dissolution studies, content of active ingredient and IR studies. The physico-chemical properties of the finished product complied with the specifications. In vitro release from the formulation was studied as per the USP XXIII dissolution procedure. The formulations gave a normal release effect followed by sustained release for 12 h which indicates bimodal release of ziprasidone HCl from the matrix tablets. The data obtained was fitted to Peppas models. Analysis of n values of the Korsmeyer equation indicated that the drug release involved non-diffusional mechanisms. By the present study, it can be concluded that bi-layer tablets of ziprasidone HCl and trihexyphenidyl HCl will be a useful strategy for extending the metabolism and improving the bioavailability of Ziprasidone HCl and Trihexyphenidyl HCl.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Editor:  Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação:  10.1590/S1984-82502011000300012
Formato:  text/html
Fonte:  Brazilian Journal of Pharmaceutical Sciences v.47 n.3 2011
Direitos:  info:eu-repo/semantics/openAccess

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