| Registro completo |
| Provedor de dados: |
BJPS
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| País: |
Brazil
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| Título: |
Statistical optimization of dithranol-loaded solid lipid nanoparticles using factorial design
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| Autores: |
Gambhire,Makarand Suresh
Bhalekar,Mangesh Ramesh
Gambhire,Vaishali Makarand
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| Data: |
2011-09-01
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| Ano: |
2011
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| Palavras-chave: |
Solid lipid nanoparticles
Homogenization
Ultrasonication
3² factorial design
Dithranol
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| Resumo: |
This study describes a 3² full factorial experimental design to optimize the formulation of dithranol (DTH) loaded solid lipid nanoparticles (SLN) by the pre-emulsion ultrasonication method. The variables drug: lipid ratio and sonication time were studied at three levels and arranged in a 3² factorial design to study the influence on the response variables particle size and % entrapment efficiency (%EE). From the statistical analysis of data polynomial equations were generated. The particle size and %EE for the 9 batches (R1 to R9) showed a wide variation of 219-348 nm and 51.33- 71.80 %, respectively. The physical characteristics of DTH-loaded SLN were evaluated using a particle size analyzer, differential scanning calorimetry and X-ray diffraction. The results of the optimized formulation showed an average particle size of 219 nm and entrapment efficiency of 69.88 %. Ex-vivo drug penetration using rat skin showed about a 2-fold increase in localization of DTH in skin as compared to the marketed preparation of DTH.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000300008
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| Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
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| Relação: |
10.1590/S1984-82502011000300008
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.47 n.3 2011
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| Direitos: |
info:eu-repo/semantics/openAccess
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