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Provedor de dados:  BJPS
País:  Brazil
Título:  Development and validation of a fluorimetric method to determine curcumin in lipid and polymeric nanocapsule suspensions
Autores:  Mazzarino,Letícia
Bellettini,Ismael Casagrande
Minatti,Edson
Lemos-Senna,Elenara
Data:  2010-06-01
Ano:  2010
Palavras-chave:  Curcumin/determination
Fluorimetric method/quantitative analysis
Polymeric nanocapsules/evaluation
Lipid nanocapsules/evaluation
Resumo:  A simple, rapid, and sensitive fluorimetric method was developed and validated to quantify curcumin in lipid and polymeric nanocapsule suspensions, using acetonitrile as a solvent. The excitation and emission wavelengths were set at 397 nm and 508 nm, respectively. The calibration graph was linear from 0.1 to 0.6 µg/mL with a correlation coefficient of 0.9982. The detection and quantitation limits were 0.03 and 0.10 µg/mL, respectively. The validation results confirmed that the developed method is specific, linear, accurate, and precise for its intended use. The current method was successfully applied to the evaluation of curcumin content in lipid and polymeric nanocapsule suspensions during the early stage of formulation development.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000200008
Editor:  Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação:  10.1590/S1984-82502010000200008
Formato:  text/html
Fonte:  Brazilian Journal of Pharmaceutical Sciences v.46 n.2 2010
Direitos:  info:eu-repo/semantics/openAccess
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