| Registro completo |
| Provedor de dados: |
BJPS
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| País: |
Brazil
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| Título: |
Development and validation of a fluorimetric method to determine curcumin in lipid and polymeric nanocapsule suspensions
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| Autores: |
Mazzarino,Letícia
Bellettini,Ismael Casagrande
Minatti,Edson
Lemos-Senna,Elenara
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| Data: |
2010-06-01
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| Ano: |
2010
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| Palavras-chave: |
Curcumin/determination
Fluorimetric method/quantitative analysis
Polymeric nanocapsules/evaluation
Lipid nanocapsules/evaluation
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| Resumo: |
A simple, rapid, and sensitive fluorimetric method was developed and validated to quantify curcumin in lipid and polymeric nanocapsule suspensions, using acetonitrile as a solvent. The excitation and emission wavelengths were set at 397 nm and 508 nm, respectively. The calibration graph was linear from 0.1 to 0.6 µg/mL with a correlation coefficient of 0.9982. The detection and quantitation limits were 0.03 and 0.10 µg/mL, respectively. The validation results confirmed that the developed method is specific, linear, accurate, and precise for its intended use. The current method was successfully applied to the evaluation of curcumin content in lipid and polymeric nanocapsule suspensions during the early stage of formulation development.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000200008
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| Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
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| Relação: |
10.1590/S1984-82502010000200008
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.46 n.2 2010
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| Direitos: |
info:eu-repo/semantics/openAccess
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