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Provedor de dados:  60
País:  Brazil
Título:  Alternative methods in toxicity testing: the current approach
Autores:  Araújo,Gabrielle Luck de
Campos,Maria Augusta Amaral
Valente,Maria Anete Santana
Silva,Sarah Cristina Teixeira
França,Flávia Dayrell
Chaves,Miriam Martins
Tagliati,Carlos Alberto
Data:  2014-03-01
Ano:  2014
Palavras-chave:  Toxicology/alternative methods
Toxicological analysis/alternative methods
Toxicology/21st
Century
Animals/use in experiments
Resumo:  Alternative methods are being developed to reduce, refine, and replace (3Rs) animals used in experiments, aimed at protecting animal welfare. The present study reports alternative tests which are based on the principles of the 3Rs and the efforts made to validate these tests. In Europe, several methodologies have already been implemented, such as tests of irritability, cell viability, and phototoxicity as well as in vitro mathematical models together with the use of in silico tools. This is a complex process that spans from development to regulatory approval and subsequent adoption by various official entities. Within this regulatory framework is REACH, the European Community Regulation for chemicals and their safe use. In Brazil, the BraCVAM (Brazilian Center for the Validation of Alternative Methods) was recently established to validate alternative methods and stimulate incorporation of new methodologies. A new vision of toxicology is emerging for the 21st century (Tox-21), and the subsequent changes are shaping a new paradigm.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000100005
Editor:  Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação:  10.1590/S1984-82502011000100005
Formato:  text/html
Fonte:  Brazilian Journal of Pharmaceutical Sciences v.50 n.1 2014
Direitos:  info:eu-repo/semantics/openAccess
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