| Registro completo |
| Provedor de dados: |
BJPS
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| País: |
Brazil
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| Título: |
A quantitative study of the influence of coprocessing of binders on the mechanical properties of paracetamol tablets
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| Autores: |
Ogunjimi,Abayomi Tolulope
Alebiowu,Gbenga
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| Data: |
2010-06-01
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| Ano: |
2010
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| Palavras-chave: |
Coprocessing
Neem gum
Microcrystalline cellulose
Binder
Tensile strength
Brittle fracture index
Paracetamol
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| Resumo: |
A 2³ factorial experimental design has been used to quantitatively study individual and interaction effects of the nature of binder (N), concentration of binder (C) and the applied pressure (P) on two mechanical properties, namely, tensile strength (TS) and brittle fracture index (BFI), of paracetamol tablets. The factorial design was also used to study the quantitative effects of coprocessing of binders on the mechanical properties. The results obtained from this study suggest that the nature (i.e. plastic/elastic) and ratio of binders coprocessed together alter the influence of C and P on TS and BFI.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000200006
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| Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
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| Relação: |
10.1590/S1984-82502010000200006
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.46 n.2 2010
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| Direitos: |
info:eu-repo/semantics/openAccess
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