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Provedor de dados:  Ciência Rural
País:  Brazil
Título:  Can Triamcinolone acetonide, platelet-rich plasma, and pentosan polysulfate sodium induce oxidative stress in cultured equine chondrocytes?
Autores:  Palma,Heloisa Einloft
Silva,Gabriele Biavaschi da
Salazar,Rodrigo Fernando dos Santos
Krause,Luciana Maria Fontanari
Brass,Karin Erica
Corte,Flavio Desessards De La
Data:  2019-01-01
Ano:  2019
Palavras-chave:  Antioxidant enzymes
Glutathione peroxidase
Lipid peroxidation
Resumo:  ABSTRACT: Progressive deterioration and loss of articular cartilage are the final degenerative events common to osteoarthritis (OA). Reactive oxygen species (ROS) play an important role in this chondrocyte catabolic activity, leading to cell death and matrix components breakdown. Intra-articular corticosteroid injections such as triamcinolone acetonide have been used to control pain and inflammation associated with OA. New treatments for OA, platelet-rich plasma and pentosan polysulphate sodium have also been used and further investigations are necessary to determine their safety in joint cells. In this in vitro study, the use of these three substances (triamcinolone acetonide, platelet-rich plasma, and pentosan polysulphate sodium) in healthy chondrocytes did not alter the antioxidant status when compared to control groups, indicating that they could be considered safe in healthy conditions.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Editor:  Universidade Federal de Santa Maria
Relação:  10.1590/0103-8478cr20180263
Formato:  text/html
Fonte:  Ciência Rural v.49 n.7 2019
Direitos:  info:eu-repo/semantics/openAccess

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