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Provedor de dados:  65
País:  Brazil
Título:  Lamellar keratoplasty in rabbits using an allogeneic free omental graft and omentum-derived mesenchymal cells associated with the canine amniotic membrane
Autores:  Barros,Séfora Vieira da Silva Gouvêa de
Aldrovani,Marcela
Lacerda,Luciana Cenço Correa de
Horr,Mônica
Marinho,Fábio Andrade
Lima,Tiago Barbalho
Silveira,Camila Pinho Balthazar da
Brito,Fábio Luiz da Cunha
Bassaneze,Vinícius
Flecher,Mayra Cunha
Beltrame,Renato Travassos
Nakamuta,Juliana Sanajotti
Krieger,José Eduardo
Laus,José Luiz
Oliveira,Krishna Duro de
Data:  2016-10-01
Ano:  2016
Palavras-chave:  Amniotic membrane
Cornea
Omentum
Progenitor cells
Wound healing.
Resumo:  ABSTRACT: The objective of this research was to evaluate the clinical and microscopic effects in rabbits of lamellar keratoplasty using allogeneic omentum associated with canine amniotic membrane (AM). Rabbits were divided into two groups: one received the allogeneic free omental graft covered with the AM (OM-graft group), while the other received the AM graft containing omental mesenchymal cells (OM-cell group). Clinical signs were evaluated on different postoperative days. After the clinical assessments, the rabbits were euthanized and their corneas were obtained for histopathology and immunohistochemistry (Ki-67, marker for proliferation). Both groups showed chemosis, blepharospasm, eye discharge, hyperemia, and corneal opacity/edema. Neovascularization was observed in the OM-cell group. Histopathological evaluation revealed epithelial islands within the stroma of OM-cell samples. Thirty days after surgery, complete corneal re-epithelialization had occurred in both groups. The OM-cell group showed more Ki-67 positive cells. The free omentum and its cells, combined with the AM, contributed to corneal repair, a process that was completed 30 days after lamellar keratoplasty.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016001001838
Editor:  Universidade Federal de Santa Maria
Relação:  10.1590/0103-8478cr20151348
Formato:  text/html
Fonte:  Ciência Rural v.46 n.10 2016
Direitos:  info:eu-repo/semantics/openAccess
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