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Provedor de dados:  Ciência Rural
País:  Brazil
Título:  Activity of the antimicrobial peptide P34 against bovine alphaherpesvirus type 1
Autores:  Castro,Clarissa Caetano de
Silva,Débora Scopel e
Costa,Géssica Aracéli
Vargas,Gilberto D’Avila
Lima,Marcelo de
Motta,Amanda de Souza da
Hübner,Silvia de Oliveira
Data:  2017-01-01
Ano:  2017
Palavras-chave:  Antiviral
Resumo:  ABSTRACT: Previous studies have demonstrated the antimicrobial activity of the peptide P34. In this study, the antiviral potential of P34 and the in vitro mechanism of action were investigated against bovine alphaherpesvirus type 1 (BoHV1). P34 exhibited low toxicity, a high selectivity index (22.9) and a percentage of inhibition of up to 100% in MDBK cells. Results from antiviral assays indicated that P34 did not interact with cell receptors, but it was able to inhibit the viral penetration immediately after pre-adsorption. In addition, BoHV1 growth curve in MDBK cells in the presence of P34 revealed a significant reduction in virus titer only 8h post-infection, also suggesting an important role at late stages of the replicative cycle. Virucidal effect was observed only in cytotoxic concentrations of the peptide. These findings showed that the antimicrobial peptide P34 may be considered as a potential novel inhibitor of in vitro herpesviruses and must encourage further investigation of its antiherpetic activity in animal models as well as against a wide spectrum of viruses.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Editor:  Universidade Federal de Santa Maria
Relação:  10.1590/0103-8478cr20160668
Formato:  text/html
Fonte:  Ciência Rural v.47 n.6 2017
Direitos:  info:eu-repo/semantics/openAccess

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