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Provedor de dados:  Genet. Mol. Biol.
País:  Brazil
Título:  Effects of polymorphisms in APOB, APOE, HSD11β1, PLIN4, and ADIPOQ genes on lipid profile and anthropometric variables related to obesity in children and adolescents
Autores:  Gasparin,Caroline C.
Leite,Neiva
Tureck,Luciane V.
Souza,Ricardo L.R.
Milano-Gai,Gerusa E.
Silva,Larissa R.
Lopes,Wendell A.
Furtado-Alle,Lupe
Data:  2018-12-01
Ano:  2018
Palavras-chave:  PLIN4 gene
APOB gene
ADIPOQ gene
HSD11β1 gene
APOE gene
Resumo:  Abstract Genes can influence lipid profile and anthropometric variables related to obesity. The present study aimed to verify if variants of the APOE, APOB, ADIPOQ, HSD11β1, and PLIN4 genes are associated with lipid levels or anthropometric variables in a sample comprised of 393 Euro-Brazilian children and adolescents. DNA was genotyped by TaqMan allelic discrimination assay. The ε4 and ε2 alleles of the APOE gene were associated respectively with lower high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels (p=0.015 and p=0.012, respectively), while the ε3 allele was associated with higher abdominal circumference (p=0.0416) and excess weight (p=0.0001). The G allele (rs846910) of the HSD11β1 gene was also associated with excess weight (p=0.039). No other association was found. Our results indicate that the ε4 and ε2 alleles could contribute to lower HDL-C and LDL-C levels, respectively, furthermore, the ε3 allele and the G allele (rs846910) of HSD11β1 gene may be risk factors for excess of weight.These findings are very important because we observed that some genetic variants influence the lipid profile and anthropometric variables early in life.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000500735
Editor:  Sociedade Brasileira de Genética
Relação:  10.1590/1678-4685-gmb-2017-0195
Formato:  text/html
Fonte:  Genetics and Molecular Biology v.41 n.4 2018
Direitos:  info:eu-repo/semantics/openAccess
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