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Provedor de dados:  Genet. Mol. Biol.
País:  Brazil
Título:  Gender-dependent association of HSD11B1 single nucleotide polymorphisms with glucose and HDL-C levels
Autores:  Turek,Luciane Viater
Souza,Ricardo Lehtonen Rodrigues
Lima,Jovana Karoline
Milano,Gerusa Eisfeld
Timossi,Luciana da Silva
Osiecki,Ana Claudia Vecchi
Alle,Lupe Furtado
Data:  2014-09-01
Ano:  2014
Palavras-chave:  HSD11B1 gene
Metabolic syndrome
Resumo:  In this study, we investigated the influence of two SNPs (rs846910 and rs12086634) of the HSD11B1 gene that encodes 11β-hydroxysteroid dehydrogenase type 1(11β-HSD1), the enzyme that catalyzes the conversion of cortisol to cortisone, on variables associated with obesity and metabolic syndrome in 215 individuals of both sexes from southern Brazil. The HSD11B1 gene variants were genotyped using the TaqMan SNP genotyping assay. Glucose, triglycerides, total cholesterol, HDL-cholesterol and LDL-cholesterol were measured by standard automated methods. Significant results were found in women, with carriers of the G allele of SNP rs12086634 having higher glucose levels than non-carriers. Carriers of the A allele of SNP rs846910 had higher levels of HDL-cholesterol. The involvement of both polymorphisms as independent factors in determining the levels of glucose and HDL-cholesterol was confirmed by multiple regression analysis (β = 0.19 ± 0.09, p = 0.03 and β = 0.22 ± 0.10, p = 0.03, respectively). Our findings suggest that the HSD11B1SNPs studied may indirectly influence glucose and HDL-cholesterol metabolism in women, possibly through down-regulation of the HSD11B1 gene by estrogen.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Editor:  Sociedade Brasileira de Genética
Relação:  10.1590/S1415-47572014000400003
Formato:  text/html
Fonte:  Genetics and Molecular Biology v.37 n.3 2014
Direitos:  info:eu-repo/semantics/openAccess

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