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Provedor de dados:  Genet. Mol. Biol.
País:  Brazil
Título:  Molecular evolution and functional divergence of alcohol dehydrogenases in animals, fungi and plants
Autores:  Thompson,Claudia E.
Freitas,Loreta B.
Salzano,Francisco M.
Data:  2018-01-01
Ano:  2018
Palavras-chave:  Glycolytic proteins
Molecular evolution
Alcohol dehydrogenase
Functional diversification
Positive selection
Resumo:  Abstract Alcohol dehydrogenases belong to the large superfamily of medium-chain dehydrogenases/reductases, which occur throughout the biological world and are involved with many important metabolic routes. We considered the phylogeny of 190 ADH sequences of animals, fungi, and plants. Non-class III Caenorhabditis elegans ADHs were seen closely related to tetrameric fungal ADHs. ADH3 forms a sister group to amphibian, reptilian, avian and mammalian non-class III ADHs. In fishes, two main forms are identified: ADH1 and ADH3, whereas in amphibians there is a new ADH form (ADH8). ADH2 is found in Mammalia and Aves, and they formed a monophyletic group. Additionally, mammalian ADH4 seems to result from an ADH1 duplication, while in Fungi, ADH formed clusters based on types and genera. The plant ADH isoforms constitute a basal clade in relation to ADHs from animals. We identified amino acid residues responsible for functional divergence between ADH types in fungi, mammals, and fishes. In mammals, these differences occur mainly between ADH1/ADH4 and ADH3/ADH5, whereas functional divergence occurred in fungi between ADH1/ADH5, ADH5/ADH4, and ADH5/ADH3. In fishes, the forms also seem to be functionally divergent. The ADH family expansion exemplifies a neofunctionalization process where reiterative duplication events are related to new activities.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Editor:  Sociedade Brasileira de Genética
Relação:  10.1590/1678-4685-gmb-2017-0047
Formato:  text/html
Fonte:  Genetics and Molecular Biology v.41 n.1 suppl.1 2018
Direitos:  info:eu-repo/semantics/openAccess

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