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Provedor de dados:  74
País:  Brazil
Título:  Article Molecular analysis of three FUT3 gene single nucleotide polymorphisms and their relationship with the lewis erythrocytary phenotype in a human population of japanese-ancestry living in Tomé Açu, a town in the Brazilian Amazon
Autores:  Francez,Pablo Abdon da Costa
Corvelo,Tereza Cristina de Oliveira
Silva,Flávio Ricardo Leal da
Santos,Sidney Emanuel Batista dos
Data:  2007-03-01
Ano:  2007
Palavras-chave:  Lewis blood groups
FUT3
Japanese
PCR-RFLPs
SNPs
Resumo:  The Lewis blood group system involves two major antigens, Leª and Le b. Their antigenic determinants are not primary gene products but are synthesized by the transfer of sugar subunits to a precursory chain by a specific enzyme which is the product of the FUT3 gene (Lewis gene). The presence of three FUT3 gene single nucleotide polymorphisms (SNPs) (59T > G; 508G > A and 1067T > A) was related to the Lewis phenotype of erythrocytes from 185 individuals of Japanese ancestry living in the town of Tomé-Açu in the Brazilian Amazon region. This relationship was detected using a serological hemagglutination test and the Dot-ELISA assay along with the molecular technique PCR-RFLP. We found that the three SNPs investigated in this study only accounted for a proportion of the Lewis-negative phenotype of the erythrocytes.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000300002
Editor:  Sociedade Brasileira de Genética
Relação:  10.1590/S1415-47572007000300002
Formato:  text/html
Fonte:  Genetics and Molecular Biology v.30 n.2 2007
Direitos:  info:eu-repo/semantics/openAccess
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