| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
|
| País: |
Brazil
|
| Título: |
Article Molecular analysis of three FUT3 gene single nucleotide polymorphisms and their relationship with the lewis erythrocytary phenotype in a human population of japanese-ancestry living in Tomé Açu, a town in the Brazilian Amazon
|
| Autores: |
Francez,Pablo Abdon da Costa
Corvelo,Tereza Cristina de Oliveira
Silva,Flávio Ricardo Leal da
Santos,Sidney Emanuel Batista dos
|
| Data: |
2007-03-01
|
| Ano: |
2007
|
| Palavras-chave: |
Lewis blood groups
FUT3
Japanese
PCR-RFLPs
SNPs
|
| Resumo: |
The Lewis blood group system involves two major antigens, Leª and Le b. Their antigenic determinants are not primary gene products but are synthesized by the transfer of sugar subunits to a precursory chain by a specific enzyme which is the product of the FUT3 gene (Lewis gene). The presence of three FUT3 gene single nucleotide polymorphisms (SNPs) (59T > G; 508G > A and 1067T > A) was related to the Lewis phenotype of erythrocytes from 185 individuals of Japanese ancestry living in the town of Tomé-Açu in the Brazilian Amazon region. This relationship was detected using a serological hemagglutination test and the Dot-ELISA assay along with the molecular technique PCR-RFLP. We found that the three SNPs investigated in this study only accounted for a proportion of the Lewis-negative phenotype of the erythrocytes.
|
| Tipo: |
Info:eu-repo/semantics/article
|
| Idioma: |
Inglês
|
| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000300002
|
| Editor: |
Sociedade Brasileira de Genética
|
| Relação: |
10.1590/S1415-47572007000300002
|
| Formato: |
text/html
|
| Fonte: |
Genetics and Molecular Biology v.30 n.2 2007
|
| Direitos: |
info:eu-repo/semantics/openAccess
|
