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Provedor de dados:  Genet. Mol. Biol.
País:  Brazil
Título:  Proportional odds model applied to mapping of disease resistance genes in plants
Autores:  Spyrides-Cunha,Maria Helena
Demétrio,Clarice G.B.
Camargo,Luis E.A.
Data:  2000-03-01
Ano:  2000
Resumo:  Molecular markers have been used extensively to map quantitative trait loci (QTL) controlling disease resistance in plants. Mapping is usually done by establishing a statistical association between molecular marker genotypes and quantitative variations in disease resistance. However, most statistical approaches require a continuous distribution of the response variable, a requirement not always met since evaluation of disease resistance is often done using visual ratings based on an ordinal scale of disease severity. This paper discusses the application of the proportional odds model to the mapping of disease resistance genes in plants amenable to expression as ordinal data. The model was used to map two resistance QTL of maize to Puccinia sorghi. The microsatellite markers bngl166 and bngl669, located on chromosomes 2 and 8, respectively, were used to genotype F2 individuals from a segregating population. Genotypes at each marker locus were then compared by assessing disease severity in F3 plants derived from the selfing of each genotyped F2 plant based on an ordinal scale severity. The residual deviance and the chi-square score statistic indicated a good fit of the model to the data and the odds had a constant proportionality at each threshold. Single-marker analyses detected significant differences among marker genotypes at both marker loci, indicating that these markers were linked to disease resistance QTL. The inclusion of the interaction term after single-marker analysis provided strong evidence of an epistatic interaction between the two QTL. These results indicate that the proportional odds model can be used as an alternative to traditional methods in cases where the response variable consists of an ordinal scale, thus eliminating the problems of heterocedasticity, non-linearity, and the non-normality of residuals often associated with this type of data.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572000000100039
Editor:  Sociedade Brasileira de Genética
Relação:  10.1590/S1415-47572000000100039
Formato:  text/html
Fonte:  Genetics and Molecular Biology v.23 n.1 2000
Direitos:  info:eu-repo/semantics/openAccess
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