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Provedor de dados:  Genet. Mol. Biol.
País:  Brazil
Título:  Effects of Maytenus ilicifolia Mart. and Bauhinia candicans Benth infusions on onion root-tip and rat bone-marrow cells
Autores:  Camparoto,Marjori Leiva
Teixeira,Rosangela de Oliveira
Mantovani,Mário Sérgio
Vicentini,Veronica Elisa Pimenta
Data:  2002-01-01
Ano:  2002
Palavras-chave:  Allium cepa test
Bauhinia candicans
Chromosome damage
Maytenus ilicifolia
Medicinal herbs
Mutagenicity test
Wistar rat bone marrow cells
Resumo:  Medicinal plants are widely used to treat various diseases, and in Brazil the plants Maytenus ilicifolia Mart. and Bauhinia candicans Benth are commonly used in popular medicine. However, there are a large number of compounds in plants which can produce alterations in genetic material, and this study was conducted to investigate any possible mutagenic and cytotoxic effects that M. ilicifolia and B. candicans infusions may have on the cell cycle and chromosomes. Infusions were prepared with in natura leaves to give two concentrations of infusions, one at the concentration normally used by the population in general and the other at 10 times this value (i.e. 3.5 and 35 mg/mL for M. ilicifolia and 0.465 and 4.65 mg/mL for B. candicans). Onion (Allium cepa L.) root-tip cells (RTC) and Wistar rat bone-marrow cells (BMC) were used as test systems in in vivo assays. The M. ilicifolia infusions at both concentrations, and the B. candicans infusion at the lower concentration, had no statistically significant depressive mitotic effect on RTC. A statistically significant depressive mitotic effect on RTC was found with the more concentrated (4.65 mg/mL) B. candicans infusion as compared with a negative control. In BMC, infusions of B. candicans and M. ilicifolia produced no statistically significant increase in the number of chromosome alterations or rates of cell division as compared to controls. The significance of these findings are discussed in the light of the use of these plants as therapeutic agents.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Editor:  Sociedade Brasileira de Genética
Relação:  10.1590/S1415-47572002000100016
Formato:  text/html
Fonte:  Genetics and Molecular Biology v.25 n.1 2002
Direitos:  info:eu-repo/semantics/openAccess

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