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Provedor de dados:  International Journal of Morphology
País:  Chile
Título:  Apoptosis in Bone Defect of Diabetic Rats Treated with Low Intensity Laser: Radiological and Immunohistochemical Approach
Autores:  da Silva,Jairo Pinheiro
de Carvalho,Camila Albuquerque Mello
Romualdo,Andressa Rodrigues
Schiavoni,Vagner Sarraipo
Barbosa,Marcello Henrique Nogueira
de Moraes,Marcella Suélen Torrecilla
Tirapelli,Daniela Petri Cunha
Fazan,Valéria de Paula Sassoli
Thomazini,José Antônio
Tirapelli,Luis Fernando
Data:  2017-03-01
Ano:  2017
Palavras-chave:  Bone defect
Diabetes mellitus
Laser therapy
Regeneration
Apoptosis
Resumo:  The aim of this study is evaluate the efficacy of 904 nm laser diode in bone regeneration in the bone defect in diabetic rats. Six groups of 10 male Wistar rats and 2 mm bone defects drilled on the left and right tibia were used. The diabetic animals were treated with streptozotocin (40 mg/kg, i.v.). We compared the diode laser doses of treatment of bone defects 50 w ­ 4 J/cm and 100 w ­ 4J/. The right tibia was used for immunohistochemical analysis with the apoptosis markers XIAP and Caspase-3 and the left tibia was submitted to computer tomography (CT). Caspase-3 marker showed greater amount of apoptosis in all the untreated groups compared to both laser treatments. There was no statistical significance for XIAP marker. CT scan showed improvement of bone defect area and volume in both laser treated groups, control and diabetic. Therefore the low intensity laser therapy was effective in accelerating bone repair in both, control and diabetic groups. It was evidenced in our study that diabetes influences bone repair negatively.
Tipo:  Journal article
Idioma:  Inglês
Identificador:  http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000100029
Editor:  Sociedad Chilena de Anatomía
Formato:  text/html
Fonte:  International Journal of Morphology v.35 n.1 2017
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